The unique kelp ingredient in ProDen PlaqueOff® - A.N ProDen™ - is a 100% natural and organic kelp, sustainably harvested from specially selected locations in the fresh, cold North Atlantic waters off the Scandinavian coastline— one of the purest habitats on earth. Being exposed to these extreme environmental conditions and processed in a unique, specially developed process, it naturally develops and achieve the highest quality and maximum effect, making it safe and healthy for your pet.